Stephy Publishers

 Efficacy And Safety of Nifuratel-Nystatin in The Treatment of Mixed Vaginitis, in Pregnant Women From Quindío, 2013-2017. Randomized Clinical Trial Women with abnormal vaginal discharge usually suffer from bacterial vaginosis (BV), vulvovaginal candidiasis (VVC), trichomonas vaginitis (TV) or any combination of these. Objective: To compare the efficacy and safety of the combination nifuratel-nystatin with metronidazole -nystatin in the treatment of mixed vaginitis in pregnant women, and its adverse effects. Materials and methods: Randomized, double-blind, parallel-group clinical trial in 153 pregnant women, diagnosed with mixed vaginitis; in a complex private medical institution in Armenia (Colombia), between 2013 and 2017. The patients were randomized 1:1 to receive a daily intravginal egg for six days: nifuratel (500mg) - nystatin (200,000 IU) (Group "A") and metronidazole (500mg) - nystatin (100,000 IU) (Group "B"). A follow-up of the healing of symptoms was det...

 The Concept of Clinical Endometriosis: A Paradigm Shift in Africa The clinical symptoms of endometriosis, an illness characterized by ectopic endometrium (glands and stroma) outside the uterus, are mainly dysmenorrhea, dyspareunia, cyclic urinary symptoms and infertility. Although imaging modalities such as pelvic ultrasound can identify and localize endometriotic deposits in the ovary (endometrioma) and in bladder wall, diagnosis of the disease is impossible where such imaging modalities are unavailable or where clinicians are not trained to clinically diagnose endometriosis during consultation. Especially in sub-Saharan Africa, clinicians should be familiar with certain predisposing risk factors for endometriosis such as early age at menarche, shorter menstrual length and low body mass index. Delay in the diagnosis of endometriosis not only prolongs the duration of suffering, pain and discomfort but also lowers quality of life and increases cost of treatment. This article focuse...

Improving and addressing lymphocytes response against SARS-CoV-2 and its variants with intralveolar BCG administration   Bacillus Calmette Guerin administered by the aerosol route may locally elicit and increase T1 lymphocyte response in pulmonary alveoli, which are the main target of SARS-2-CoV-2 and its variants, thus preventing and anticipating the virus attack. This may lead to a decrease of the most severe forms of the disease considered as an acute autoimmune virus inducted disease. The lymphocyte response may start to work before and regardless of anti-CoVid vaccination. Since November 2019 a pandemic infection due to the SARSCoV-2 virus is still expanding in the world through human-to-human transmission. It affects the respiratory tract, mainly the lungs, but in its most serious forms can also impact other major organs such as kidney, intestine, heart and brain. This infection has the following characteristics: a) It is rapidly contagious via airborne droplets containing vi...

  Risks and Benefits of HRT Versus ERT in Order to Separate HRT from ERT While the benefits of Hormone Replace Therapy (HRT) and Estrogen Replace Therapy (ERT) might overlap, their risks have to be separated particularly with regard to breast cancer. The risks of HRT are mainly Coronary Heart Disease (CHD) and Breast cancer. The main risk of ERT is the incidence of strokes which can be avoided by not using an oral estrogen but an Intra-uterine contraceptive but reducing the risk of endometrial cancer in women with a womb. Studies that randomized peri-menopausal and menopausal women to either HRT or ERT versus placebo and one study that included similar women followed up prospectively for the incidence of the development of Alzheimer’s Dementia (AD). Results: The significant risks of HRT included CHD, stroke and pulmonary embolism. The risk of breast cancer only really existed after long term follow-up [(annualized incidence, 0.45% vs 0.36%; Hazard Ratio (HR) 1.28)]. The significant...

 Characterization of Lesions in the Central Nervous System Based on Neurosonography and Magnetic Resonance in Fetus with Isolated Congenital Heart Defects. A Systematic Review Congenitalheartdefectsrepresentoneofthemainmalformationsdiagnosed prenatally. These are a major cause of neuro developmental disorders and it has even been proposed that structural brain alteration is found from early stages of fetal development. Objective: The objective of this study was to review the existing evidence of prenatal diagnosis of structural braina lterations found in fetal brain magnetic resonance imaging and neurosonography in fetus with isolated congenital heart defect. Materials and Methods: A search of Pubmed, Science Direct, Clinical Key and EBSCO databases was conducted in order to review study cases of fetuses with congenital heart defect between 18 and 37 week with Doppler ultrasonography, neurosonography and /or fetal brain magnetic resonance imaging. Results: A total of 16 articles we...

 Breastfeeding and Gestational Diabetes: Overview in México Gestational diabetes mellitus is defined as glucose intolerance first detected during pregnancy. Maternal obesity and gestational diabetes mellitus have been associated with more difficulties in the establishment and duration of breastfeeding among mothers with gestational diabetes mellitus who have a body mass index above their healthy, normal weight counterparts; plus the large number of social and economic factors that prevent the establishment of satisfactory breastfeeding, makes it essential to provide systematic support, especially in the first days of life, remembering that breastfeeding in turn reduces the risk of diabetes in women. Mexico is a middle-high income Latin American country; studies conducted in metropolitan areas with larger populations indicate that exclusive breastfeeding is often initiated, but it is difficult to continue it; together with the increase in the prevalence of obesity and diabetes melli...

 Risks of Gynecological Illnesses in Different ABO Blood Groups of Black Women with Primary or Secondary Infertility in Sub-Saharan Africa: A Preliminary Study Background: The aim of this investigation was twofold: first, to determine an association between types of infertility and ABO blood group and, second, to show potential risk ratios of different gynecological diseases in ABO blood groups. Method: Two hundred and fifty-one women with primary or secondary infertility who presented at a tertiary health facility in Lagos were studied retrospectively. All the cases were seen by consultant gynecologists and all had their ABO blood groups and Rhesus factor determined by standard techniques, though ABO blood group is reported in this study. Statistical methods included mean and standard deviation, χ2, risk ratios and odd ratios (95% CI). P-value was set to be significant at <0.05. Results: O blood group was dominant (n=125, 49.8%) in the study population. Women with primary infer...