Malignancy in a Family with Carney’s Complex| Stephy Publishers

 


Clinical Diabetes and Endocrinology - (JCDE)| Stephy Publishers

Abstract

Carney Complex is a genetic disease characterized by skin lentigenes and freckling and the growth of benign tumors in endocrine glands as well as cardiac myxoma. Malignant tumors in Carney’s Complex are extremely rare with few other case reports. We report the rare occurrence of ovarian malignancy and thyroid carcinoma separately in 2 out of 3 family members diagnosed with Carney Complex.

Keywords
Carney Complex, Cardiac myoxomata, Eendocrine tumors, Chemotherapy, Malignant tumor

Learning Points
a) The importance of thoroughly screening all lesions in Carney’s Complex rather than dismissing them as benign, as there is still a possibility for the lesion to be malignant.

b) Malignant tumors in Carney’s complex can arise from any organ, which in the index case presented with multiple tumors over many years culminating in an ovarian malignant tumor, whereas the sister developed a thyroid malignancy.

c) Acromegaly occurring in multiple members of a family should raise the suspicion of Carney’s complex to the treating clinician.

d) All other family members of a patient presenting with Carney’s Complex should be screened as they are at risk of also developing Carney’s complex.

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https://www.stephypublishers.com/diabetes-and-endocrinology/fulltext/JCDE.MS.ID.000501.php

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