Reduced Bone Neoformation in Smoking Rat’s Calvaria Grafted with Bone Ceramic | Stephy publishers

 


Journal of Dental Research and Oral Hygiene | Stephy publishers

Abstract
The impact of cigarette smoke on bone grafts in implantodontics has been discussed in the scientific literature. The present study aimed to evaluate bone repair in calvaria of rats after the performance of critical bone defects and graft of bone ceramic biomaterial in animals exposed or not to cigarette smoke. Bone defects of 5mm in diameter were made in parietal bone. Each defect was filled with Bone Ceramic biomaterial. Twenty rats were used and divided into 2groups: test, consisting of 10rats exposed to cigarette smoke; and a control group, consisting of 10rats not exposed to cigarette smoke. The animals were euthanized in the 4th postoperative week and bone tissue samples were extracted to perform the histometric analysis. The test group showed less bone neoformation, with statistical significance (p<0.05) when compared to the control group. We conclude that cigarette smoke had a negative influence on bone neoformation.

Keywords: Bone graft, Biomaterials, Bone Ceramic, Cigarette smoke

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