m R.N.A. Purifications Process: Affinity Chromato-Graphy, Magnetic Beads and Graphene Coated Large Scale Production and Toxicological Aspects


Aim of this work is to verify the state of the art related m R.N.A. purification process , the technology used as well as the materials employed. New methods vs classic methods: the use of affinity cromato-graphy or and high‐gradient magnetic separation (H.G.M.S.). In particular the use of magnetic beads since introduction of the graphene coated ones. Various producers provide many kind of magnetic beads with various grade of efficiency in separation. Becasue today there is a great debate around graphene derivates peresence (or not) in vials of m R.N.A. VACCINE it is relevant to better clarify the production process as well and the materials used.

During last periods in order to fight Covid-19 pandemia was introduced with emergency autorization a new class of vaccine: The m R.N.A. vaccine. This innovative biopharmaceutical products was developed starting form the research in the previous decade related oncologic vaccine research. It is interestig so verifying the manifacturing process used in example to purify this molecule from the impurities or other non useful component. The classic method used solvent , but in order to increase efficiency of the process was introduced purification trough chromatographic methods ( in example affinity cromato-graphy and high efficiency methods With high-gradient magnetic separation (H.G.M.S. ) and other )

https://www.stephypublishers.com/cicmr/pdf/CICMR.MS.ID.000517.pdf



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