Hypoglycemia in Non-Diabetic Patient: Report of Two Cases of Insulinoma

Background: Insulinoma is a B-cell tumor of the islets of the pancreas with an incidence of 4 per 1 million people per year, which produces excess insulin and can cause symptoms related to hypoglycemia at the level of the central nervous system or symptoms related to excess release of compensatory catecholamines. The presence of hypoglycemia, elevated insulin, proinsulin, and c-peptide levels suggest endogenous hyperinsulinism, which together with imaging findings suggestive of neuroendocrine tumor, allow establishing the diagnostic impression of Insulinoma. Cases report: Patients with neuroglycopenic symptoms, biochemical profile of hypoglycemia, endogenous hyperinsulinemia and radiological finding compatible with insulinoma are reported, who were treated by surgical resection of the tumor, with complete resolution of the initial symptoms. Conclusion: The clinical presentation, diagnosis and treatment of insulinoma represents a clinical challenge, since it is a rare pathology and the delay in diagnosis can have catastrophic consequences for the patient, stories such as permanent brain damage and death.

Insulinoma is a B-cell tumor of the islets of the pancreas with an incidence of 4 per 1 million people a year, which produces excess insulin and may cause symptoms related to hypoglycemia in the central nervous system or symptoms related to excess release of compensating catecholamines. The presence of hypoglycemia, elevated insulin levels, proinsulin and peptide c suggest endogenous hyperinsulinism, in addition to imaging findings suggestive of neuroendocrine tumor, allow establishing the diagnostic impression of insulinoma.

https://www.stephypublishers.com/sojmccr/pdf/SOJMCCR.MS.ID.000513.pdf



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