Management of Upper Airway Bleeding in Patients Hospitalized for SARS-COV2| Stephy Publishers

 


SOJ Complementary and Emergency Medicine - (SOJCEM) | Stephy Publishers


Abstract

Spontaneous epistaxis in patients with COVID-19 can represent a clinical challenge with respect to both the risk of contamination and the treatment options. Epistaxis (nosebleed) is a common condition overall but is relatively rare in adults and older patients. We herein present the data of 25 patients with COVID-19 who developed spontaneous epistaxis while hospitalized at Centro Médico Naval from March 2020 to April 2021. All patients received low-molecular-weight heparin during their hospital stay and required supplementary oxygen therapy either by a nasal cannula, continuous positive airway pressure or ventilatory mechanical support.

In total, 12100 patients with laboratory confirmed SARS-CoV-2 infection were admitted to our hospital unit from 1 March to 31 April 2021. We only found 25 patients with epistaxis, All patients underwent anterior rhinoscopy.

In all patients, the bleeding site was identified, controlled with cauterization with silver nitrate and absorbable hemostatic material. In patients with posterior epistaxis, the posterior packing was removed after 5 days. Nasal lubricants were prescribed in all patients after bleeding was controlled. All patients required suspension of anticoagulation after the bleeding event for 48 hours.

Posterior, anterior and oropharyngeal epistaxis occurred in both sexes, in patients with comorbidities (Diabetes mellitus, hypertension, obesity) without statistical difference. In those patients who were on ventilatory mechanical support, they presented the same risk of epistaxis, however, with a small tendency to present greater anterior epistaxis, in the same way, those patients who presented anterior epistaxis had higher mortality.

Keywords

COVID, Patients, Hypertension, Obesity

Introduction

Upper airway bleeding is a potential emergency that can end fatally if not controlled quickly and accurately. Since it affects the hemodynamic balance, ventilation and makes intubation difficult if it is necessary to secure the airway.1 The SARS-CoV-2 infection includes among the clinical manifestations thrombocytopenia or thromboembolic complications, which necessitate anticoagulation or the use of vasopressors. Manipulation of the airway is necessary from the onset of suspicion of the disease; the diagnosis requires taking a nasopharyngeal swab for RT-PCR, a procedure that is associated between 5-10% with epistaxis.1

The supply of supplemental oxygen is necessary in patients who develop pneumonia 2; the use of conventional nasal tips, high-flow nasal tips and positive pressure devices are factors that can be associated with nasal bleeding; In addition, in critically ill patients with intubation, the aspiration of secretions in the oral cavity, oropharynx and hypopharynx can cause trauma to the mucosa and cause bleeding.2-4 The most frequent site of bleeding in the upper airway is located in the nose, followed by the oral cavity and pharyngeal regions. Kristensen, 2020 Epistaxis is one of the most common emergencies in Otolaryngology (ENT), it has an incidence of 13.9% in care hospitable. Kristensen, 2020  Posterior hemorrhage is the most serious presentation and is generated mainly from branches of the sphenopalatine artery.5

Mortality associated with epistaxis is 3.4%. Death is not considered to be a direct result of the bleeding. However, blood loss contributes to increased morbidity. It can be a direct cause of death from hemorrhagic shock or from aspiration of blood and clots into the lungs.6

Methods

We describe a series of cases of hospitalized patients in the COVID-19 area of the Centro Médico Naval, with a diagnosis confirmed by RT-PCR and who developed spontaneous bleeding from the upper respiratory tract and required ENT evaluation for management and control. This research was conducted in accordance with the ethical principles originating in the Declaration of Helsinki, and written informed consent was obtained from all patients. All personnel used personal protection measures (Figure 1) and international recommendations to limit exposure to aerosols during the management of bleeding in the upper respiratory tract.7,8 The examination was carried out with a headlamp . In no case was the use of endoscopes required to control bleeding.


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