Diagnostic Performance of the Leuko-CRP Index and Procalcitonin in Patients with Suspected Sepsis who Come to the Emergency Room of the IESS Riobamba Hospital in the period | Stephy Publishers

 


Current Investigations in Clinical and Medical Research - (CICMR)| Stephy Publishers


Abstract

Introduction: Syndrome systemic inflammatory response (SIRS) is activated by the presence of any organic infection to, continuing evolves sepsis, septic shock, multiple organ failure and ends in death.

Objective: Determine the utility leuco index/PCR as diagnostic early sepsis.

Materials and Methods: Research has no experimental, of type descriptive, transverse and retrospective during the period July-December 2017, in patients with suspected bacterial sepsis attending IESS Riobamba Hospital emergency. It is utilize for diagnostic validity to the calculation of sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), likelihood ratio and ROC curves.

Results: Se and videnctio as Qua r point of co ho rte of the leuco-PCR index a value of619.82 (AUC:0.85; IC-95%: 0.76-0.9 5; p<0.05) for a procalcitonin greater than or equal to 1ng/dl; while for a procalcitonin most or equal to 0.5ng/dl, an AUC: 0.8 2; CI-95 %; 0.71-0.9 2; p<0.05 ).

Conclusion: The index leuco-PCR is useful in the diagnosis of sepsis, and alternative accesib him and inexpensive compared to procalcitonin.

Keywords: Leukocytes,CRP, Procalcitonin, Sepsis,SIRS

Introduction
Sepsis is the clinical response of the systemic inflammatory response syndrome (SIRS), a complex syndrome, product of the activation of the immune system as a result of defense against an infection of any type, its evolution leads to septic shock and subsequent to multi-organ failure (FMO) the same that can end with death, whose outcome can be modified if a timely diagnosis is made.1 At present, severe sepsis persists as an important cause of morbidity and mortality, causing more than 60% of deaths in patients admitted to the intensive care unit.2 Worldwide there are 6 million deaths annually from misdiagnosed sepsis; in Europe it represents 29% of mortality, in the United States it contributes to 35% of in-hospital deaths and in Colombia mortality reaches up to 33.6%.

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