Large Coronary Intramural Hematoma Presenting as Acute Coronay Syndrome | Stephy Publishers

 


SOJ Medical and Clinical Case Reports - (SOJMCCR) | Stephy Publishers


Abstract

Isolated spontaneous coronary intramural hematoma is a unique subset of spontaneous coronary artery dissection that is characterized by a hemorrhage limited to the medial– adventitial layers, causing subsequent hematoma formation without visible intimal flaps.

It is infrequent and serious coronary vessel wall pathology, with poorly understood underlying pathogenic mechanisms. Affected individuals may present with a broad spectrum of symptoms ranging from acute coronary syndromes (ACS) to cardiogenic shock or even sudden cardiac death. The disease entity causes challenges in terms of both diagnostics and treatment strategy. We report a case of intramural coronary hematoma in a patient presenting with non ST-‐ segment elevation myocardial infarction.

Keywords

Intramural hematoma, Pathogenic mechanisms, Lumen compromise, Coronary blood, Clopidogrel

Introduction

Spontaneous coronary intramural hematoma is a unique and rare subset of spontaneous coronary artery dissection (SCAD), where a hemorrhage within the vessel wall is thought to be the underlying cause, leading to separation of the mural layers. The hematoma formation is limited to the medial–adventitial layers, and no flaps are visible when assessed with tomographic techniques.1,2 This serious condition usually presents as acute coronary syndrome (ACS), but symptoms may range from chest pain to cardiogenic shock or sudden death,1,2 depending on hematoma location, number of affected vessels, lumen compromise, and restriction of coronary blood flow. It is more frequent in young women, particularly in the peri and post-‐ partum period and with oral contraceptive use, and in young and middle-‐ aged patients without obvious cardiovascular risk factors.3,4 Management strategies may range from conservative medical treatment to percutaneous or surgical interventions depending upon the anatomy, extent of the hematoma and the clinical circumstances.5,6

Case Report

A 64-‐ year old female was admitted due to sudden onset of chest pain. Cardiovascular risk factors included hypertension. The ECG showed inverted T waves in inferior and low lateral leads and Troponin-‐ I was elevated (8,52 ng/ml). The patient was treated with a non-‐ STEMI medical treatment including aspirin, clopidogrel and low-‐ molecular weight heparin. The echocardiogram disclosed normal wall motions and preserved EF. A subacute coronary angiography showed an ectasic right coronary artery, where we detected a large intra mural hematoma starting from mid segment of the RCA. Unfortunately, neather the IVUS or the OCT is available in our hospital. We performed a coronary computed tomography for a more detailed evaluation of the morphological features of the vessel wall. We therefore decided to continue conservative treatment and intensified the medical therapy. She was discharged after one week in a stable clinical condition. A repeat angiogram three months later showed an improvement in the intra muralhematoma (Figures 1–4).

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