Significance of Cortical Micro-Infarcts in the Human Brain | Stephy Publishers

 


Innovative Journal of Neurology and Neuroscience - (IJNN) | Stephy publishers

Abstract:
Cortical micro-infarcts are due to cerebral small vessel disease. In contrast to the arteriosclerotic type of cerebral small vessel disease, cortical micro-infarcts are mainly related and due to cerebral amyloid angiopathy. Alzheimer’s disease is the most frequent neurodegenerative dementia disease associated to cerebral amyloid angiopathy and cortical micro-infarcts. Vascular dementia cannot only be due to lacunar infarcts and ischemic white matter changes, but can also be caused by cortical micro-infarcts. The latter are a frequent cause of vascular dementia and decrease globally the cerebral blood flow.
Keywords: Cortical micro-infarcts, Cerebral amyloid angiopathy, Cerebral small vessel disease, Alzheimer’s disease, Frontotemporal lobar degeneration, Lewy body disease, Progressive supranuclear palsy, Vascular dementia.
Abbreviations: CSVD, Cerebral Small Vessel Disease; CoMIs, Cortical Micro-Infarcts; VAD, Vascular Dementia; MRI, Magnetic Resonance Imaging; CAA: Cerebral Amyloid Angiopathy; AD: Alzheimer Disease; LBD: Lewy Body Disease; FTLD: Frontotemporal Lobar Degeneration; PSP: Progressive Supranuclear Palsy

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